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Polycyclic Aromatic Hydrocarbons Mediate the Association between Tobacco Smoking and Alcohol Use Disorder

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2025-02-10 19:34
조회수
15
Issue Date
2024-12
Type
Article

Authors: Dongkyu Lee ; Mun-Joo Bae ; Mi-Ji Kim ; Sung Soo Oh ; Ki Soo Park ; Chan Joo Lee ; Sungha Park ; Seung-Koo Lee ; Sang-Baek Koh ; Sun Jae Jung ; Changsoo Kim ; Jaelim Cho

Citation: YONSEI MEDICAL JOURNAL, Vol.65(12) : 752-760, 2024-12

Journal Title: YONSEI MEDICAL JOURNAL

ISSN: 0513-5796

Issue Date: 2024-12

MeSH: Adult ; Alcoholism* / epidemiology ; Firefighters ; Fluorenes ; Humans ; Male ; Middle Aged ; Naphthols ; Polycyclic Aromatic Hydrocarbons* / adverse effects ; Polycyclic Aromatic Hydrocarbons* / urine ; Surveys and Questionnaires ; Tobacco Smoking* / adverse effects ; Tobacco Smoking* / epidemiology

Keywords: Polycyclic aromatic hydrocarbons ; alcohol ; alcoholism ; smoking ; tobacco

Abstract: Purpose: Smoking is causally related to alcohol use disorder. Although polycyclic aromatic hydrocarbons (PAHs) are major neurotoxic pollutants in tobacco smoke, evidence is lacking on the role of PAHs in the relationship between smoking and alcohol use disorder. This study investigated the types of PAHs associated with smoking and whether exposure to those PAHs mediated the effect of smoking on alcohol use disorder.

Materials and methods: A total of 968 male firefighters were analyzed. Smoking history and cumulative pack-years were obtained using self-reported questionnaires. Alcohol use disorder was defined using the Alcohol Use Disorder Identification Test. PAH exposure was assessed by urinary metabolites. Regression analyses were performed between exposure (smoking), outcome (alcohol use disorder), and mediator (PAH metabolites) variables. A mediation analysis was performed to test the indirect effect of PAH metabolites on the association between smoking and alcohol use disorder. All analyses were repeated for 770 participants who were followed up after 2 years, while alcohol use disorder was redefined from follow-up data ensuring the temporal sequence of the variables.

Results: Both 2-naphthol [β=0.78, 95% confidence interval (CI): 0.59-0.98] and 2-hydroxyfluorene (β=0.69, 95% CI: 0.56-0.82) were associated with smoking history. Furthermore, 2-naphthol and 2-hydroxyfluorene mediated the associations of smoking history (proportion mediated: 14.2%, 23.6% respectively) or cumulative pack-years (proportion mediated: 14.4%, 25.4% respectively) with alcohol use disorder. The results were consistent in longitudinal settings.

Conclusion: Exposure to PAHs mediated the association between tobacco smoking and alcohol use disorder. PAH exposure from tobacco may increase the risk of addictive disorders.

Files in This Item:: T992024853.pdf Download

DOI: 10.3349/ymj.2023.0488

Appears in Collections:: 1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers

Yonsei Authors: Kim, Chang Soo(김창수) https://orcid.org/0000-0002-5940-5649
Jung, Sun Jae(정선재) https://orcid.org/0000-0002-5194-7339

URI: https://ir.ymlib.yonsei.ac.kr/handle/22282913/202408

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