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Association between respiratory tract deposited dose of size-segregated PM and FeNO based on individual exposure assessment for Korean children

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2025-02-10 19:34
조회수
14
Issue Date
2024-12
Type
Article

Authors: Kyungjun Jeong ; Yongjin Lee ; Minji Park ; Minsun Lee ; Jaelim Jo ; Sangbaek Koh ; Youngwook Lim ; Dongchun Shin ; Changsoo Kim

Citation: SCIENCE OF THE TOTAL ENVIRONMENT, Vol.957 : 177795, 2024-12

Journal Title: SCIENCE OF THE TOTAL ENVIRONMENT

ISSN: 0048-9697

Issue Date: 2024-12

MeSH: Air Pollutants* / analysis ; Air Pollution / statistics & numerical data ; Child ; Environmental Exposure* / statistics & numerical data ; Female ; Humans ; Male ; Nitric Oxide* / analysis ; Particle Size ; Particulate Matter* / analysis ; Republic of Korea ; Respiratory System

Keywords: Dosimetry ; FeNO ; Individual exposure assessment ; Respiratory deposited dose

Abstract: FeNO (fractional exhaled nitric oxide) is a crucial marker to understand children's respiratory diseases such as asthma, and severity may vary depending on PM diameter and respiratory tract region. This study investigates the relationship between size-segregated respiratory deposited PM dose and FeNO for children. Size-segregated PM (PM1.0, PM1.0-2.5, and PM2.5-10.0) and FeNO were measured for eighty children based on individual exposure assessment in five consecutive days. Individual physical activity was measured by an accelerometer device. Accordingly, a dosimetry model estimated the respiratory deposited dose by PM diameter in the extrathoracic (ET), tracheobronchial (TB), and pulmonary (PUL) regions. A linear mixed model (LMM) with distributed lag non-linear model (DLNM) was used for analysis. The effects of home environment and traffic-related factors were also examined for sensitivity analysis. We found that IQR increases of PM2.5-10.0 and PM1.0 were associated with 15.1 % (95 % CI: 3.5, 28.1) and 15.9 % (95 % CI: 2.7, 30.9) FeNO increase in respiratory Total region in 0-12 h lag. In cumulative lag 0-24 h, PM1.0 was only associated with FeNO increase: 16.6 % (95 % CI: 1.5, 34.1) in total region. No association was observed in lag 12-24 h. PM2.5-10.0 was related to short-term airway inflammation in the upper respiratory tract whereas PM1.0 has a cumulative effect on both the upper and lower respiratory tract. In sensitivity analysis, PM2.5-10.0 was associated with a 0-12 h lag, whereas both PM2.5-10.0 and PM1.0 were associated with a cumulative lag of 0-24 h. Both home environment and traffic-related factors showed a synergetic effect with PM1.0 in short-term exposure and an antagonistic effect with PM2.5-10.0 in long-term exposure. This study highlights that airway inflammation depends on PM sizes, exposure durations, and respiratory tract regions.

Full Text: https://www.sciencedirect.com/science/article/pii/S004896972407952X

DOI: 10.1016/j.scitotenv.2024.177795

Appears in Collections:: 1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers

Yonsei Authors: Kim, Chang Soo(김창수) https://orcid.org/0000-0002-5940-5649
Shin, Dong Chun(신동천) https://orcid.org/0000-0003-4252-2280
Lee, Yong Jin(이용진)
Lim, Young Wook(임영욱) https://orcid.org/0000-0001-8845-2850
Cho, Jae Lim(조재림)

URI: https://ir.ymlib.yonsei.ac.kr/handle/22282913/201555

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