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Estimates of vaccine effectiveness of the updated monovalent XBB.1.5 COVID-19 vaccine against symptomatic SARS-CoV-2 infection, hospitalization, and receipt of oxygen therapy in South Korea - October 26 to December 31, 2023

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    관리자

  • 작성일자

    2025-01-13 11:12

  • 조회수

    8

  • Issue Date

    2024-11

  • Type

    Article
Authors
 Jung Ah Lee  ;  Heeseon Jang  ;  Sang Min Ahn  ;  Jae Eun Seong  ;  Young Keun Kim  ;  Yujin Sohn  ;  Sook In Jung  ;  Hye Won Jeong  ;  Shin-Woo Kim  ;  Jin-Soo Lee  ;  Ji-Hyeon Baek  ;  Se Ju Lee  ;  Geun-Yong Kwon  ;  Jeeyeon Shin  ;  Hangjin Jeong  ;  Changsoo Kim  ;  Jun Yong Choi 
Citation
 INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, Vol.148 : 107249, 2024-11 
Journal Title
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
ISSN
 1201-9712 
Issue Date
2024-11
MeSH
Adult ; Aged ; COVID-19 Vaccines* / immunology ; COVID-19 Vaccines* / therapeutic use ; COVID-19* / immunology ; COVID-19* / prevention & control ; COVID-19* / therapy ; Case-Control Studies ; Female ; Hospitalization* / statistics & numerical data ; Humans ; Male ; Middle Aged ; Oxygen Inhalation Therapy* ; Republic of Korea / epidemiology ; SARS-CoV-2* / immunology ; Vaccination ; Vaccine Efficacy* ; Young Adult
Keywords
COVID-19 ; Vaccine ; Vaccine effectiveness ; XBB.1.5
Abstract
Objectives: We evaluated the vaccine effectiveness of monovalent XBB.1.5 vaccine against symptomatic COVID-19 infection, hospitalization, and the need for oxygen therapy in South Korea.

Design: This study employed a test-negative case-control design. COVID-19 test results in symptomatic subjects from six university hospitals across South Korea were collected (October 26-December 31, 2023). The adjusted absolute and relative vaccine effectiveness were assessed.

Results: In total, 5516 subjects were enrolled: 4,824 were unvaccinated with XBB.1.5, and 692 were vaccinated with XBB.1.5 COVID-19 mRNA vaccines. The absolute vaccine effectiveness when comparing the odds between XBB.1.5 vaccination and no vaccination against symptomatic COVID-19 infection, hospitalization, and oxygen therapy was 65.2% (95% CI, 36.1-81.0), 77.3% (95% CI, 51.1-89.5), and 85.3% (95% CI, 57.8-94.9), respectively. The relative vaccine effectiveness when comparing the odds between XBB.1.5 vaccination and no XBB.1.5 vaccination against symptomatic COVID-19 infection, hospitalization, and oxygen therapy was 57.7% (95% CI, 34.7-72.6), 64.3% (95% CI, 35.9-80.2), and 65.5% (95% CI, 27.0-83.7), respectively.

Conclusion: The short-term effectiveness of the XBB.1.5 vaccine against symptomatic COVID-19 infection, hospitalization, and receipt of oxygen therapy in South Korea was significant. Long-term vaccine effectiveness warrants evaluation, and these assessments should be conducted regularly.
Files in This Item:
T202407132.pdf Download
DOI
10.1016/j.ijid.2024.107249
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chang Soo(김창수) ORCID logo https://orcid.org/0000-0002-5940-5649
Choi, Jun Yong(최준용) ORCID logo https://orcid.org/0000-0002-2775-3315
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/201399
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Associations of per- and polyfluoroalkyl substances and heavy metals with blood lipid profiles in a representative sample of Korean adolescents
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