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Impact of physical activity levels on the association between air pollution exposures and glycemic indicators in older individuals

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2024-12-11 00:11
조회수
22
Issue Date
2024-10
Type
Article

Authors: Hyunji Park ; Sun Young Kim ; Heeseon Jang ; Yae Won Ha ; Young Mi Yun ; Kwang Joon Kim ; Yumie Rhee ; Hyeon Chang Kim ; Chang Oh Kim ; Jaelim Cho

Citation: ENVIRONMENTAL HEALTH, Vol.23(1) : 87, 2024-10

Journal Title: ENVIRONMENTAL HEALTH

Issue Date: 2024-10

MeSH: Aged ; Air Pollutants* / adverse effects ; Air Pollutants* / analysis ; Air Pollution* / adverse effects ; Air Pollution* / analysis ; Blood Glucose* / analysis ; Environmental Exposure* / adverse effects ; Environmental Exposure* / analysis ; Exercise* ; Female ; Glycated Hemoglobin / analysis ; Humans ; Insulin / blood ; Insulin Resistance ; Longitudinal Studies ; Male ; Middle Aged ; Nitrogen Dioxide* / adverse effects ; Nitrogen Dioxide* / analysis ; Particulate Matter* / adverse effects ; Particulate Matter* / analysis ; Prospective Studies

Keywords: Air pollution ; Glycemic indicators ; Older individuals ; Physical activity

Abstract: Background Air pollution may exacerbate diabetes-related indicators; however, the longitudinal associations between air pollutant concentrations and glycemic markers remain unclear. In this prospective cohort study, we examined the longitudinal associations between air pollution and glycemic indicators among older individuals with normoglycemia at baseline and determined whether these associations differed according to changes in physical activity levels.

Methods Overall, 1,856 participants (mean age, 70.9 years) underwent baseline and 4-year follow-up surveys. We used linear mixed-effect models to examine the associations between previous 1-year exposures to air pollutants and glycemic indicators. We further investigated associations between previous 5-year exposures to air pollutants and glycemic indicators after the inverse probability of treatment weighting (IPTW). We explored effect modifications by the level of physical activity maintenance and changes in metabolic equivalent of task (METs) for physical activity.

Results Levels of particulate matter with aerodynamic diameters ≤ 10 μm (PM10) and ≤ 2.5 μm, and nitrogen dioxide (NO2) were significantly associated with increased fasting blood glucose, Hemoglobin A1c, insulin, and homeostatic model assessment for insulin resistance (HOMA-IR) values. After IPTW, the associations remained significant for PM10 and NO2. The positive associations of NO2 with insulin and HOMA-IR remained significant in the maintained inactive group, but not in the maintained moderate-to-vigorous active group. The positive associations of PM10 or NO2 with insulin and HOMA-IR remained significant in the group with increased METs, but not in those with decreased METs. In the post-hoc analysis of non-linear relationships between an increase in METs and glycemic indicators, insulin and HOMA-IR remarkably increased in the higher PM10 and NO2 exposure group from the point of 12,000 and 13,500 METs-min/week increase, respectively.

Conclusions We demonstrated longitudinal associations between air pollution exposures and increased insulin resistance in older individuals. Maintaining moderate-to-vigorous physical activity may mitigate the adverse effects of air pollution on insulin resistance. In older individuals dwelling in highly polluted areas, an increase of less than 12,000 METs-min/week may be beneficial for insulin resistance.

Files in This Item:: T202406797.pdf Download

DOI: 10.1186/s12940-024-01125-8

Appears in Collections:: 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers

Yonsei Authors: Kim, Kwang Joon(김광준) https://orcid.org/0000-0002-5554-8255
Kim, Chang Oh(김창오) https://orcid.org/0000-0002-0773-5443
Kim, Hyeon Chang(김현창) https://orcid.org/0000-0001-7867-1240
Rhee, Yumie(이유미) https://orcid.org/0000-0003-4227-5638
Cho, Jae Lim(조재림)

URI: https://ir.ymlib.yonsei.ac.kr/handle/22282913/201253

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