연세대학교 의과대학 예방의학교실 정밀·디지털기반 환경의학연구실

논문(Publications)

Humidifier disinfectant exposure and lung cancer development: A propensity score matching analysis

Authors: Kim, Su Hwan ; Kang, Sungchan ; Shin, Sanghee ; Hwang, Jeong-In ; Lim, Hyungryul ; Lee, Dong-Wook ; Lee, Woojoo ; Ha, Kang Hee ; Lee, Youngmee ; Kim, Taksoo ; Kim, Hye-Jin ; Kim, Kyoung-Nam

MeSH: Adult ; Aged ; Disinfectants* / adverse effects ; Female ; Humans ; Humidifiers* / statistics & numerical data ; Incidence ; Lung Neoplasms* / chemically induced ; Lung Neoplasms* / epidemiology ; Lung Neoplasms* / etiology ; Male ; Middle Aged ; Propensity Score ; Proportional Hazards Models ; Republic of Korea / epidemiology

Keywords: Humidifier disinfectant ; Lung cancer ; Propensity score matching ; Polyhexamethylene guanidine

Abstract: Background: Although previous animal studies suggest an association between humidifier disinfectant (HD) exposure and lung cancer, epidemiological evidence remains limited. Methodology: Nationwide data from the National Health Insurance Service and survey data on the HD claimant group were used. A 1:30 propensity score matching was conducted between the HD claimant (n = 4567) and non-exposed groups (n = 153,071). Hazard ratios (HRs) and 95 % confidence intervals (CIs) were estimated using Cox proportional hazards models, incorporating a 4-year latency period. Results: After matching, the incidence of lung cancer was 2.58 % in the HD claimant group and 0.55 % in the non-exposed group. In the Cox models, the HR for lung cancer in the HD claimant group was 5.71 (95 % CI: 4.70, 6.92) compared with the non-exposed group. Stratified analyses showed an HR of 12.61 (95 % CI: 8.94, 17.79) among women and 4.31 (95 % CI: 3.40, 5.47) among men. The associations also persisted in never-smokers, with an HR of 4.33 (95 % CI: 2.26, 8.30). Conclusions: Exposure to HDs was associated with an increased risk of lung cancer development. Combined with in vivo and in vitro studies reporting similar associations and plausible mechanisms, the present study supports the potential carcinogenic effects of HDs on lung cancer.

Full Text: https://www.sciencedirect.com/science/article/pii/S1877782125002425

Appears in Collections:: 1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers

Humidifier disinfectant exposure and lung cancer development: A propensity score matching analysis

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