연세대학교 의과대학 예방의학교실 정밀·디지털기반 환경의학연구실

논문(Publications)

HOME
논문(Publications)

Combined effects of particulate and gaseous pollutants on Alzheimer's disease-related brain imaging markers and cognitive function

작성자
관리자
작성일자
2026-02-19 18:04
조회수
17
Issue Date
2025-12
Type
Article

Authors: Heeseon Jang ; Hyunji Park ; Young Noh ; Sang-Baek Koh ; Seung-Koo Lee ; Jung Il Lee ; Ho Hyun Kim ; Sun-Young Kim ; Jaelim Cho ; Changsoo Kim

Citation: ENVIRONMENTAL POLLUTION, Vol.386 : 127260, 2025-12

Journal Title: ENVIRONMENTAL POLLUTION

ISSN: 0269-7491

Issue Date: 2025-12

Keywords: Air pollutants ; Alzheimer's disease ; Mixture analysis ; Neuroimaging ; Neuropsychological tests

Abstract: The combined effects of various air pollutants on Alzheimer's disease (AD)-specific brain structural pathologies are poorly understood, and whether these effects lead to impairments in specific cognitive domains has not been determined. We examined the associations between exposure to air pollutant mixtures and subclinical AD-related brain imaging markers, and then assessed whether AD-specific cortical atrophy mediated the association between air pollution exposure and specific cognitive domains. This cross-sectional study included 649 adults without dementia (≥50 years) residing in 2 metropolitan and 2 small cities in the Republic of Korea, all of whom underwent brain magnetic resonance imaging scan and neuropsychological testing. The 5-year average concentrations of particulate and gaseous pollutants were estimated at participants' residential addresses. To estimate the combined effects of these pollutant mixtures, we applied Bayesian kernel machine regression (BKMR) to capture potential non-linearity and interaction effects, and quantile g-computation (QGcomp) to estimate overall mixture effects. We additionally performed partial least squares structural equation modeling to test mediation pathways via brain cortical atrophy in the association between air pollutant mixtures and cognitive domains. BKMR analysis indicated significant associations between air pollutant mixtures and AD-related imaging markers, while QGcomp analysis revealed associations with reduced whole-brain cortical thickness. NO2 exhibited the most prominent effects on subclinical imaging markers. AD-specific cortical atrophy fully mediated the associations of air pollutant mixtures with language, visual memory, and frontal/executive functions, and partially mediated those with visuospatial function, with the greatest mediation effect observed for visuospatial function, followed by language, visual memory, and frontal/executive function. These findings suggest that exposure to air pollutant mixtures may be associated with AD-specific cortical atrophy and a subsequent decline in cognitive functions in dementia-free adults.

Full Text: https://www.sciencedirect.com/science/article/pii/S0269749125016343

DOI: 10.1016/j.envpol.2025.127260

Appears in Collections:: 1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

Yonsei Authors: Kim, Chang Soo(김창수) https://orcid.org/0000-0002-5940-5649
Lee, Seung Koo(이승구) https://orcid.org/0000-0001-5646-4072
Jang, Heeseon(장희선) https://orcid.org/0000-0002-9737-7220
Cho, Jae Lim(조재림)

URI: https://ir.ymlib.yonsei.ac.kr/handle/22282913/209168

사서에게 알리기

Humidifier disinfectant exposure and lung cancer development: A propensity score matching analysis

이전글이 없습니다.